The Hawkeyes (9-6, 2-2) are coming off an eight-point loss to Ohio State and an overtime win at Minnesota in the new year.
Michigan State (9-7, 1-3) has had a rough go of it lately, losing four of its last five.
The Spartans have won seven of the last eight games against Iowa, including both meetings last season.
Michigan State is led by Allyssa DeHaan, a 6-foot-9 sophomore who has four double-doubles this season and ranks fifth in the Big Ten in scoring (16.1 ppg) and fourth in rebounding (13.9).
The Spartans start three freshman, while Iowa’s first five are all upperclassmen.