AP Photo Mad Magazine cartoonist Al Jaffee attends an event to honor veteran contributors of MAD Magazine at the Savannah College of Art and Design and the National Cartoonists Society in 2011 in Savannah, Ga. Jaffee died Monday at the age of 102.

NEW YORK — Al Jaffee, Mad magazine’s award-winning cartoonist and ageless wise guy who delighted millions of kids with the sneaky fun of the Fold-In and the snark of “Snappy Answers to Stupid Questions,” has died. He was 102.

Jaffee died Monday in Manhattan from multiple organ failure, according to his granddaughter, Fani Thomson. He had retired at the age of 99.

Mad magazine, with its wry, sometimes pointed send-ups of politics and culture, was essential reading for teens and preteens during the baby-boom era and inspiration for countless future comedians. Few of the magazine’s self-billed “Usual Gang of Idiots” contributed as much — and as dependably — as the impish, bearded cartoonist. For decades, virtually every issue featured new material by Jaffee. His collected “Fold-Ins,” taking on everyone in his unmistakably broad visual style from the Beatles to TMZ, was enough for a four-volume box set published in 2011.

Readers savored his Fold-Ins like dessert, turning to them on the inside back cover after looking through such other favorites as Antonio Prohías’ “Spy vs. Spy” and Dave Berg’s “The Lighter Side.” The premise, originally a spoof of the old Sports Illustrated and Playboy magazine foldouts, was that you started with a full-page drawing and question on top, folded two designated points toward the middle and produced a new and surprising image, along with the answer.

The Fold-In was supposed to be a onetime gag, tried out in 1964 when Jaffee satirized the biggest celebrity news of the time: Elizabeth Taylor dumping her husband, Eddie Fisher, in favor of “Cleopatra” co-star Richard Burton. Jaffee first showed Taylor and Burton arm in arm on one side of the picture, and on the opposite side a young, handsome man being held back by a policeman.

Fold the picture in and Taylor and the young man are kissing.

The idea was so popular that Mad editor Al Feldstein wanted a follow-up. Jaffee devised a picture of 1964 GOP presidential contenders Nelson Rockefeller and Barry Goldwater that, when collapsed, became an image of Richard Nixon.

“That one really set the tone for what the cleverness of the Fold-Ins has to be,” Jaffee told the Boston Phoenix in 2010. “It couldn’t just be bringing someone from the left to kiss someone on the right.”